Laboratory of Advances in New Drug Formulations

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Laboratory of Advances in New Drug Formulations

The Laboratory of Advances in New Drug Formulations includes two laboratories, where research is conducted that can also constitute the basis for an offer for external entities. The laboratory maintains permanent cooperation with a pharmaceutical company.

Work group of drug formulations and ecotoxicity studies
The following research is conducted in the laboratory:

  1. Research on the stability of drugs and other chemical substances, which include:
    • determining their stability in constant temperature and air humidity provided by a climatic chamber with a built-in thermo-hygrostat,
    • determining their stability under the influence of light, in constant temperature provided by a constant-temperature chamber


    Equipment for drug stability research in constant temperature conditions: climatic chamber

  2. Active substance release studies from various pharmaceutical formulations using USP 1, USP 2 type test methods, in accordance with the American, European and Japanese Pharmacopoeias.

    Active substance dissolution apparatus

  3. Ecotoxicity tests of chemicals against Aliivibrio fischeri bacteria (Microtox® test and its modification for testing poorly soluble substances) including:
    • analysis of toxicity of chemicals and their mixtures, including poorly soluble substances, e.g. pharmaceuticals,
    • analysis of ecotoxicity of real samples (water, soil, sediments, sewage),
    • tests in accordance with EN ISO 11348–3.

    Microtox® ecotoxicity testing apparatus

    Work group supervisor: dr Marika Turek
    e-mail: m.turek@ujd.edu.pl

    X-ray structural analysis work group

    The laboratory conducts structural studies by X-ray diffraction on single crystals of various organic, inorganic and complex chemical compounds, including compounds with biological activity, using the Xcalibur™3 X-ray diffractometer equipped with a CCD camera, Cu lamp and a temperature attachment to maintain a constant sample temperature in the range of 90 to 490K.

    Xcalibur™3 X-ray diffractometer

    Work group supervisor: dr Ewa Różycka-Sokołowska
    e-mail: e.sokolowska@ujd.edu.pl

    Research projects of the Laboratory staff:

    1. OPUS 9 (/B/ST5/03541)
    Title: Design of new chiral and achiral quaternary heteronium salts with assumed herbicidal properties and study of their eco(phyto)toxicity, project manager: prof. P. Bałczewski
    The aim of the project was to conduct research consisting of: 1) finding non-toxic substitutes for the herbicide glyphosate (Roundup®), which in chemical terms would also be derivatives of acetic acid but would contain a different sequence of heteroatoms than glyphosate, and 2) establishing the relationship between the chemical structure of such compounds and the properties oriented towards their herbicidal activity.

    2. PRELUDIUM 17 (N/ST5/01602)
    Title: Co-crystallization and co-amorphization of angiotensin II receptor blockers leading to more soluble compounds with bifunctional action, project manager; dr M. Turek, project supervisor: prof. P. Bałczewski
    The aim of the project is to obtain bifunctional antihypertensive drugs based on APIs from the group of angiotensin II receptor blockers with the addition of a nutraceutical co-former, in the project, in addition to classical methods of synthesis of co-crystals and co-amorphous solids, sonochemical and mechanochemical methods are used.

    Scientific achievements of the Laboratory staff in 2020-2024:

    1. Ecotoxicity of ammonium chlorophenoxyacetate derivatives towards aquatic organisms: Unexpected enhanced toxicity upon oxygen by sulfur replacement, M.Turek, B.Pawłowska, E.Różycka-Sokołowska, R.Biczak, J.Wilk, K.Owsianik, B.Marciniak, P.Bałczewski, J.Haz.Mat. 382, 121086, (2020) IF2022 =14.224, 200 pkt.
    2. Modification of the Microtox® Basic Solid Phase Test: a New Application for The Ecotoxicological Studies on Poorly Soluble Antihypertensive Drugs, M.Turek, E.Różycka-Sokołowska, K.Owsianik, B. Marciniak, P.Bałczewski, J.Haz.Mat. 399, 122839, (2020) IF2022 =14.224, 200 pkt.
    3. P.Bałczewski, J.Wil,k Quinquevalent phosphorus acids in Organophosphorus Compounds, (review 01.01.2018 - 31.12.2018) D. W. Allen, D. Loakes, L. J. Higham, J. C. Tebby (Eds.), RSC Publishing Home- Royal Society of Chemistry, Vol. 49, 198-331, (2020)
    4. The hetero-Friedel-Crafts-Bradsher cyclizations with formation of ring carbon-heteroatom (P, S) bonds, leading to organic functional materials, J. Skalik, M. Koprowski, E. Różycka-Sokołowska, P. Bałczewski, Materials, 13, 4751, (2020) IF2022 = 3.748,140 pkt.
    5. Organosulfur Materials with High Photo- and Photo-oxidation Stability: 10-Anthryl Sulfoxides and Sulfones and Their Photophysical Properties Dependent on the Sulfur Oxidation State, P. Bałczewski, E. Kowalska, E. Różycka-Sokołowska, P. Uznański, J. Wilk, M. Koprowski, K. Owsianik, B.Marciniak, Materials, 14, 3506, (2021) IF2022 = 3.748,140 pkt.
    6. Role of Hydrogen Bonds in Formation of Co-amorphous Valsartan/Nicotinamide Compositions of High Solubility and Durability with Anti-hypertension and Anti-COVID-19 Potential, M. Turek,; E. Różycka-Sokołowska, M. Koprowski, B. Marciniak, P. Bałczewski, Molecular Pharmaceutics, 18,1970-1984, (2021) IF2022 = 5.364, 140 pkt.
    7. P. Bałczewski, K. Owsianik Quinquevalent phosphorus acids In: Organophosphorus Compounds, (review 01.01.2019 - 31.12.2019) D. W. Allen, D. Loakes, L. J. Higham, J. C. Tebby (Eds.), RSC Publishing Home- Royal Society of Chemistry, Vol. 50, 271- 408 (2021)
    8. Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for ItsDetermination in Plant Seeds, E. Jaszczak-Wilke, Ż. Polkowska, M. Koprowski, K. Owsianik, A. E. Mitchell, P. Bałczewski, Molecules 26, 2253, (2021) IF2022 =4.927, 140 pkt.
    9. P. Bałczewski, K. Owsianik, M. Turek, Quinquevalent phosphorus acids In: Organophosphorus Compounds, (review 01.01.2020 - 31.12.2020) J. Higham, D. W. Allen, L. J. C. Tebby (Eds.), RSC Publishing Home - Royal Society of Chemistry, Vol. 51, 181-327 (2022)
    10. The need to change the approach to the safe use of herbicides by developing chiral and environmentally friendly formulations: a series of enantioselective (R)- and (S)-phenylethylammonium chloroacetates, M.Turek, R. Biczak, B. Pawłowska, E. Różycka-Sokołowska, K. Owsianik, B. Marciniak, P. Bałczewski, Green Chemistry, 2022, 24, 1693 - 1703 IF2022 = 11.034, 200 pkt.
    11. Comprehensive review on synthesis, properties and applications of phosphorus (P III , P IV , P V ) substituted acenes with more than two fused benzene rings, M.Koprowski, K.Owsianik, Ł.Knopik, V.Vivek, A.Romaniuk, E.Różycka-Sokołowska, P.Bałczewski, Molecules, 2022, 27, 6611, IF2022 = 4.927, 140 pkt
    12. O,S-Acetals in a new modification of the oxo-Friedel-Crafts-Bradsher cyclization – synthesis of fluorescent (hetero)acenes and mechanistic considerations, K. Owsianik , E.Różycka-Sokołowska, P.Bałczewski, Molecules, 2023, 28, 2474. IF2022 = 4.927, 140 pkt
    13. Can pharmaceutical excipients threaten the aquatic environment? – a risk assessment based on the Microtox® biotest, M.Turek, E.Różycka-Sokołowska, M.Koprowski, B.Marciniak, P.Bałczewski, Molecules 2023, 28, 6590, IF2023 = 4.6, 140 pkt
    14. P. Bałczewski, K. Owsianik Quinquevalent phosphorus acids In: Organophosphorus Compounds, (review 01.01.2021 - 31.12.2022) D. W. Allen, D. Loakes, L. J. Higham, J. C. Tebby (Eds.), RSC Publishing Home- Royal Society of Chemistry, Vol. 52, (2023)
    15. Highly substituted 10-RO-(hetero)acenes - electric properties of vacuum deposited molecular films, B. Marciniak, S. Kania, P. Bałczewski, E. Różycka-Sokołowska, J. Wilk, M. Koprowski, J. Stańdo, J. Kuliński, Molecules, 2023, 28, 6422. IF2023 = 4.6, 140 pkt.
    16. New perspectives for antihypertensive sartans as components of co-crystals and co-amorphous solids with improved properties and multipurpose activity, M.Turek, E. Różycka-Sokołowska, K. Owsianik, P. Bałczewski, Molecular Pharmaceutics, 2024, 21, 1, 18-37, IF = 5.364, 140 pkt.
    17. The first example of the Friedel–Crafts cyclization leading to (10-hydroxy-9,10-dihydroanthr-9-yl)phosphonium salts without the expected Bradsher dehydration, K. Owsianik, E. Różycka-Sokołowska, M. Koprowski, M. Turek, Ł. Knopik, V. Vivek, B. Dudziński, P. Bałczewski, International Journal of Molecular Sciences, 2024, 25, 1741. IF = 4.9, 140 pkt.
    18. Comprehensive Review of Synthesis, Optical Properties and Applications of Heteroarylphosphonates and Their Derivatives, K. Owsianik, A. Romaniuk, M. Turek, P. Bałczewski, Molecules 2024, 29, 3691, IF2024 = 4.2, 140 pkt


    Patent applications and patents of the Laboratory staff in 2020-2024:

    1.Zastosowanie medyczne beta-glukanu z owsa
    P. Bałczewski, J. Kaźmierczak-Barańska, M. Cieślak, B. Nawrot
    T. Zając, D. Nazarkiewicz- Zając
    Patent PL-235190 przyznany 12.02.2020 (P-421338, 19.04.2017).

    2.Stała ko-amorficzna dyspersja walsartanu, sposób jej syntezy
    oraz jej medyczne zastosowanie
    Turek, M., Różycka-Sokołowska, E., Makowska-Janusik, M., Bałczewski, P.,
    Owsianik, K., Koprowski, M.
    Zgłoszenie patentowe P-433749, 29.04.2020.

    3.Sposób biotestowania ekotoksyczności substancji i mieszanin w fazieskondensowanej oraz jego zastosowanie w ekotoksykologii
    M.Turek, P. Bałczewski, E. Różycka-Sokołowska, M. Koprowski, K. Owsianik
    Zgłoszenie patentowe P-433623, 22.04.2020.

    4.Nowe policykliczne, skondensowane węglowodory aromatyczne i heteroaroma-tyczne, sposób ich wytwarzania oraz związki pośrednie”P. Bałczewski, A. Bodzioch, J.Skalik, wysłany 23.09.2011.
    Nr P-396700 (19.10.2011).,
    Patent PL-235186, udzielony 23.01.2020.(P-396700, 19.10.2011).

    5.3-Aryl-2-phosphoryl substituted 1-indanones and the method for their
    preparation
    P. Bałczewski, D. Szczęsna,European patent application, Sub. No 2519665,Appl. No EP-14150858 (12.01.2014) EP14460079,
    Numer patentu EP3045462A1,udzielony 25.03.2020.

    6.A solid co-amorphous dispersion of valsartan, a method for synthesizing the same and a medical use of the dispersion
    Turek, M., Różycka-Sokołowska, E.,Makowska-Janusik, M., Bałczewski, P.,
    WO 2021/221521, Publikacja 04.11.2021 (na podstawie P.433749, 29.04.2020)
    Walidacja: US2023172854 (A1), 2023-06-08.

    7.A method for biotesting of a condensed phase substances and/or mixtures ecotoxicity and use of the method in ecotoxicology.
    M.Turek, P. Bałczewski, E. Różycka-Sokołowska, M. Koprowski, K. Owsianik
    WO 2021/215944, Publikacja 25.10.2021 (na podstawie P.433623, 22.04.2020).

    8. Skondensowane węglowodory aromatyczne podstawione grupamifosforoorganicznymi, sposób ich wytwarzania, związki pośrednie oraz zastosowanie
    P.Bałczewski, B.Dudziński, M.Koprowski, Ł.Knopik. K.Owsianik
    Zgłoszenie patentowe P-438275, 26.06.2021.

    9.Tio-sfunkcjonalizowane aceny i ich zastosowanie
    P.Bałczewski, E.Kowalska, J.Skalik, M.Koprowski, K.Owsianik, E.Różycka-Sokołowska
    Patent udzielony PL241401 udzielony 26.09.2022 na podstawiezgłoszenia patentowego P.429239, 12.03.2019.

    10.Wysoko podstawione 10-(difenylofosfinoilo)antraceny, sposób ich wytwarzania i zastosowanie
    V. Vivek, P.Bałczewski, M. Koprowski, K.Owsianik, E. Różycka-Sokołowska,
    Zgłoszenie patentowe P-445384, 28.04.2023

    11. Skondensowane węglowodory aromatyczne podstawione grupami fosforoorganicznymi, sposób ich wytwarzania, związki pośrednie oraz zastosowanie
    P. Bałczewski, B. Dudziński, M.Koprowski, Ł.Knopik. K. Owsianik
    Patent PL-245310 udzielony 21.06.2024 na podstawie zgłoszenia patentowego P-438275, 26.06.2021.

Head of the Laboratory: prof. dr hab. Piotr Bałczewski

E-mail: p.balczewski@ujd.edu.pl